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(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine → (2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine | HCID 9799042 | — |
| 反応物 | Hydrochloride methanol | HCID 21893726 | — |
| 生成物 | (2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride | HCID 9954592 | 85% |
反応手順
Compound 4 (89 mg, 0.25 mmol) was treated with hydrogen chloride-methanol (5 ml). After the solvent was evaporated in vacuo, the residue (pale yellow solid) was recrystallized from ethanol-diethyl ether to give Compound 5 (91 mg, 85%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789423 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-f263c02321954e629af05718b16c72d2 |
| 出典メモ | uspto-grants-1998_08 |