Water → 4-(1,1-Dicyanoethyl)anisole

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Methyl iodide	HCID 6328	—
反応物	Sodium hydride	HCID 24758	—
反応物	(4-Methoxyphenyl)malononitrile	HCID 641441	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	4-(1,1-Dicyanoethyl)anisole	HCID 19066445	268.5%

反応手順

To a mixture of Compound 35 (1.0 g, 6.0 mmol) and NaH (280 mg, 7.0 mmol) in DMF (12 ml) was added MeI (1.0 g, 7.0 mmol) at room temperature. After the mixture was stirred for 22 hours, the mixture was poured into H2O (30 ml), and extracted with CH2Cl2. The combined extracts were dried (Na2SO4), and concentrated to give a yellow oil (3 g), which was purified by a column chromatography on silica gel to give Compound 35 as a colorless solid (900 mg, 81%).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US05789423
出典データセット	uspto-grants-1998_08
ORD ID	ord-1f92e4c444b74b1aa93def5842cf23b9
出典メモ	uspto-grants-1998_08