Water → HCID 19067073、化合物

HRID 481763ノート

反応式

HRID 481763 の反応式
I[CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1.[N-:14]=[N+:15]=[N-:16].[Na+].O.ClCCl>CN(C)C=O>[N:14]([CH:2]1[C:8](=[O:9])[NH:7][C:6]2[N:10]=[CH:11][CH:12]=[CH:13][C:5]=2[CH2:4][CH2:3]1)=[N+:15]=[N-:16]

参加物

6

反応物 4

HCID 962WaterHCID 6344DichloromethaneHCID 33557Sodium AzideHCID 190670745,6,7,9-Tetrahydro-7-iodo-8H-pyrido[2,3-b]azepin-8-one

生成物 1

HCID 19067073HCID 19067073、化合物収率 94.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
20 °C

実験手順

To 333 mg of the intermediate obtained in Step G in 6 mL of dimethylformamide (DMF) was added 600 mg of sodium azide. The mixture was stirred at 20° C. 20 h before addition of water and extraction with dichloromethane. The extracts were combined and dried over sodium sulfate. Evaporation of the solvent gave 223 mg of the product characterized by its NMR and mass spectra.

後処理

  1. dry with materialdried over sodium sulfate
  2. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-9c8fea675a4c426d9124058290234526
出典データセット
uspto-grants-1998_08
特許番号
US05789587

反応ノート

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