Benzylamine → N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine

HRID 48184

反応式

HRID 48184 の反応式
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)CCC>[CH2:15]([NH:22][C:4]1[N:3]=[C:2]([Cl:1])[N:10]=[C:9]2[C:5]=1[N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

生成物 1

HCID 10733091N-Benzyl-2-chloro-9-isopropyl-9H-purin-6-amine収率 85%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

2,6-dichloro-9-isopropylpurine (1 mmol) and benzylamine (3.5 mmol) were heated with stirring in 3 ml of n-butanol (3 hour, 110° C.). The reaction mixture (after evaporation of n-butanol) was worked up as above for the compound 2, yield 85-90%.

後処理

  1. customThe reaction mixture (after evaporation of n-butanol)

出典と根拠

ORDレコード
ord-d2bcde2ca2704df1811ca52f0c53f035
出典データセット
uspto-grants-2004_03
特許番号
US06703395B2

関連ノート

読み込み中…