5-Bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole → 5-Bromo-3-(piperidin-4-yl)-1H-indole

HRID 481945ノート

反応式

HRID 481945 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH:16]=1.[H][H]>[Pt].[Pt]=O.C(OC(=O)C)C.O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1

参加物

6

反応物 2

HCID 27637245-Bromo-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 112429275-Bromo-3-(piperidin-4-yl)-1H-indole収率 75.6%

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 82844Platinum oxide (PtO)触媒HCID 21939870Tetrahydrofuran ethyl acetate溶媒

実験手順

To a solution of 13.61 gm (49 mmol) 5-bromo 3-[1,2,3,6-tetrahydro-4-pyridinyl]-1H-indole in 75 ml 2:1 tetrahydro-furan ethyl acetate were added 8.0 gm 3% sulfided platinum on carbon and 4.0 gm platinum oxide. The reaction mixture was hydrogenated with an initial hydrogen pressure of 60 p.s.i. at 40° C. for 18 hours and then at ambient temperature for 30 hours. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to give 10.33 gm (75.6%) of the title compound as a light yellow solid.

後処理

  1. waitat ambient temperature for 30 hours
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-3b7960c8df6a49329e071789304e5601
出典データセット
uspto-grants-1998_08
特許番号
US05792760

反応ノート

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