Ethanol → N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

HRID 48201

反応式

HRID 48201 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O.I[CH2:15][CH3:16].[CH3:17][CH2:18][OH:19]>>[CH2:15]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[NH:1][C:18](=[O:19])[CH3:17])[CH2:9]1)[CH3:16]

参加物

4

反応物 3

HCID 702EthanolHCID 6340IodoethaneHCID 690855-Nitroisoquinoline

生成物 1

HCID 10398491N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

実験手順

A solution of 5-nitroisoquinoline (25 g, 0.144 mol) in 250 mL of EtOH was treated with iodoethane (26.9 g, 0.172 mol) and the resulting solution heated at reflux for 24 hours. The reaction mixture was cooled and the material which formed was collected and dried. The material obtained was converted to the title compound by the procedures described in Example 1. A white solid was obtained (4.42 g, 17%).

後処理

  1. temperaturethe resulting solution heated
  2. temperatureat reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. customthe material which formed
  5. customwas collected
  6. customdried
  7. customThe material obtained

出典と根拠

ORDレコード
ord-63374dd46e7b4aceb47f36df2ff1252c
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

関連ノート

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