8-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine → HCID 10058790、化合物

HRID 48206ノート

反応式

HRID 48206 の反応式
Br[C:2]1[C:11]2[CH2:10][N:9]([CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:6]=2[C:5]([NH2:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1>CO.[Pd]>[CH2:12]([N:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:2][CH:3]=[C:4]([NH2:16])[C:5]=2[NH2:15])[CH2:10]1)[CH2:13][CH3:14]

参加物

4

反応物 1

HCID 104257568-Bromo-1,2,3,4-tetrahydro-6-nitro-2-propyl-5-isoquinolinamine

生成物 1

HCID 10058790HCID 10058790、化合物収率 129.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of the product from Example 12 (1.50 g, 4.77 mmol) and 20% Pd on carbon (0.30 g) in 75 mL of MeOH was hydrogenated at room temperature and pressure for 24 hours. The reaction mixture was concentrated and the residue was suspended in iPr2O and collected by filtration to give the title compound as a yellow solid (1.27 g, 93%).

後処理

  1. customwas hydrogenated at room temperature
  2. concentrationThe reaction mixture was concentrated
  3. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-5ac0eb774d324534a4d251b21c2c0b90
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

反応ノート

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