Benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester → Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester

HRID 482113

反応式

HRID 482113 の反応式
C([O:8][C:9]1[CH:10]=[C:11]([O:16][S:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:19])=[O:18])[CH:12]=[C:13]([CH3:15])[CH:14]=1)C1C=CC=CC=1>[Pd].C(O)C>[OH:8][C:9]1[CH:10]=[C:11]([O:16][S:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)(=[O:19])=[O:18])[CH:12]=[C:13]([CH3:15])[CH:14]=1

参加物

4

反応物 1

HCID 54005214Benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester

生成物 1

HCID 11054545Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester収率 98.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of benzenesulfonic acid 3-benzyloxy-5-methylphenyl ester (532 mg, 1.5 mmol), as prepared in the preceding step, and 10% palladium on carbon (200 mg) in ethanol (20 mL) was hydrogenated (balloon) overnight. The catalyst was removed by filtering over diatomaceous earth and the filtrate was evaporated in vacuo to give the title compound as a colorless syrup (390 mg, 98%). 1H-NMR (300 MHz, CDCl3 /CD3OD) δ 2.19 (s, 3H), 6.27 (s, 1H), 6.54 (s, 1H), 6.66 (s 1H), 7.43 (m, 1H), 7.55 (t, 1H), 7.70 (t, 1H), 7.85 (m, 2H).

後処理

  1. custom(balloon) overnight
  2. customThe catalyst was removed
  3. filtrationby filtering over diatomaceous earth
  4. customthe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-07fbf5c563664a749808f9942eb4a60d
出典データセット
uspto-grants-1998_08
特許番号
US05792769

関連ノート

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