5-Bromo-8-nitroisoquinoline → 5-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline

HRID 48212

反応式

HRID 48212 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.C([BH3-])#N.[Na+]>C(O)(=O)C.O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

参加物

5

反応物 2

HCID 8169835-Bromo-8-nitroisoquinolineHCID 5003444Sodium cyanoborohydride

生成物 1

HCID 100380655-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

Alternatively, a solution of 5-bromo-8-nitroisoquinoline (1.0 g) in glacial acetic acid (30 mL) was cooled to 0° C. and, before freezing, was treated with sodium cyanoborohydride (1.10 g). The reaction mixture was warmed slowly to room temperature under nitrogen. The reaction mixture was diluted with water and basified. Organic layer extracts were chromatographed on silica gel as before.

後処理

  1. customOrganic layer extracts were chromatographed on silica gel as before

出典と根拠

ORDレコード
ord-92c435d16a5e4d599305b982937720f7
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

関連ノート

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