5-Bromo-1,2,3,4-tetrahydro-2-methyl-7-nitro-8-isoquinolinamine → 5-Bromo-1,2,3,4-tetrahydro-2-methyl-7,8-isoquinolinediamine
反応式
[Br:1][C:2]1[CH:11]=[C:10]([N+:12]([O-])=O)[C:9]([NH2:15])=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:16])[CH2:7]2>C1COCC1.[Ni]>[Br:1][C:2]1[CH:11]=[C:10]([NH2:12])[C:9]([NH2:15])=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:16])[CH2:7]2参加物
4
実験手順
A solution of the product from Example 60 (1.02 g, 3.49 mmol) in 50 mL THF was treated with Raney nickel (prewashed with acetone followed by THF), and the reaction vessel was purged with H2. After stirring for 2.5 hours, the catalyst was removed by filtration and the filtrate evaporated to give a tan oil. The product was used without further purification.
後処理
- customthe reaction vessel was purged with H2
- customthe catalyst was removed by filtration
- customthe filtrate evaporated
- customto give a tan oil
- customThe product was used without further purification
出典と根拠
- ORDレコード
- ord-c8ab3f5e8e5a4aebae8cd41a5c2b99fd
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703391B2
反応ノート
読み込み中…