[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester → HCID 20633122、化合物

HRID 48234ノート

反応式

HRID 48234 の反応式
C([O:3][C:4](=O)[C:5]([N:7]([CH2:21][CH2:22][CH2:23][CH3:24])[C:8]1[C:17]([N+:18]([O-])=O)=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)=[O:6])C>C(O)(=O)C.[Pd]>[CH2:21]([N:7]1[C:8]2[C:9]3[CH2:10][CH2:11][CH2:12][NH:13][C:14]=3[CH:15]=[CH:16][C:17]=2[NH:18][C:4](=[O:3])[C:5]1=[O:6])[CH2:22][CH2:23][CH3:24]

参加物

4

反応物 1

HCID 53663592[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester

生成物 1

HCID 20633122HCID 20633122、化合物収率 71%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

A solution of the product from Example 88 (0.63 g) in 75 mL of acetic acid was treated with 56 Pd/C (0.2 g) and shaken on a Parr apparatus under a hydrogen atmosphere (52 psi) for 12 hours. The catalyst was removed by filtration and the filtrate evaporated. The residue was washed with ether to give the title compound (0.35 g, 71% yield).

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. washThe residue was washed with ether

出典と根拠

ORDレコード
ord-7ef201be0f5a416b828d947e63f1f096
出典データセット
uspto-grants-2004_03
特許番号
US06703391B2

反応ノート

読み込み中…