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Sodium borohydride → Methyl (2-hydroxymethyl-5-methylphenoxy)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Methyl (2-formyl-5-methylphenoxy)acetate | HCID 54288233 | — |
| 触媒 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl (2-hydroxymethyl-5-methylphenoxy)acetate | HCID 54364037 | 82.9% |
反応手順
By the method of Example 1, Step G, 11.27 g (0.054 mole) of methyl (2-formyl-5-methylphenoxy)acetate was reacted with 0.54 g (0.014 mole) of sodium borohydride and 0.10 g (0.0018 mole) of sodium methoxide in 30 mL of methanol, yielding 9.41 g of methyl (2-hydroxymethyl-5-methylphenoxy)-acetate as a yellow oil. The NMR spectrum was consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05798316 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-e37de4ebdd6549958563c391f485231f |
| 出典メモ | uspto-grants-1998_08 |