Sodium borohydride → Methyl 2-(4-hydroxymethylphenoxy)propionate

HRID 482427ノート

反応式

HRID 482427 の反応式
[CH:1]([C:3]1[CH:15]=[CH:14][C:6]([O:7][CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1)=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[CH:15]=[CH:14][C:6]([O:7][CH:8]([CH3:13])[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 18981016Methyl 2-(4-formylphenoxy)propanoate

生成物 1

HCID 18759642Methyl 2-(4-hydroxymethylphenoxy)propionate収率 83.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

By the method of Example 1, Step G, 11.1 g (0.0533 mole) of methyl 2-(4-formylphenoxy)propionate and 2.02 g (0.0533 mole) of sodium borohydride were reacted in methanol, yielding 9.31 g of methyl 2-(4-hydroxymethylphenoxy)propionate as a yellow oil. The NMR spectrum was consistent with the proposed structure.

出典と根拠

ORDレコード
ord-680b883fb65b40a5ae136934f369be29
出典データセット
uspto-grants-1998_08
特許番号
US05798316

反応ノート

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