Sulfuric acid magnesium salt (1:1) → 2-Methyl-2,3-dihydrobenzofuran-7-amine

HRID 482958ノート

反応式

HRID 482958 の反応式
[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1.[H][H].S([O-])([O-])(=O)=O.[Mg+2]>[Ni].O1CCCC1>[NH2:11][C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 135358252,3-Dihydro-2-methyl-7-nitrobenzofuranHCID 178418361HCID 178418361、化合物

生成物 1

HCID 135358262-Methyl-2,3-dihydrobenzofuran-7-amine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 81 g of 1B, 400 ml of tetrahydrofuran (THF) and 3 g of activated Raney nickel catalyst was shaken under 35 p.s.i.g. hydrogen pressure at room temperature for 4 hours. The resulting mixture was treated with 20 g of magnesium sulfate, filtered and the solvent was evaporated from the filtrate, to give 7-amino-2,3-dihydro-2-methylbenzofuran (1C), as an amber syrup.

後処理

  1. filtrationfiltered
  2. customthe solvent was evaporated from the filtrate

出典と根拠

ORDレコード
ord-5e300ed198aa443a82891f599d71acb8
出典データセット
uspto-grants-1986_03
特許番号
US04577011

反応ノート

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