Nitric Acid → HCID 178526772、化合物

反応式

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:12])=[C:7]([N+:13]([O-:15])=[O:14])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

参加物

反応物 2

HCID 944Nitric Acid

HCID 178516426HCID 178516426、化合物

生成物 1

HCID 178526772HCID 178526772、化合物

実験手順

7-Chloro-4-hydroxyquinoline (35 g, 0.195 mol; available from Aldrich, Milwaukee, Wis.) and nitric acid (350 mL of 70%) were combined and heated at reflux for 75 minutes. The reaction mixture was poured over ice while still hot. The resulting bright yellow precipitate was isolated by filtration and then washed 3 times with boiling ethyl acetate to provide 17.3 g of 7-chloro-3-nitro-4-hydroxyquinoline as a pale yellow solid.

後処理

temperatureheated
temperatureat reflux for 75 minutes
additionThe reaction mixture was poured over ice while still hot
customThe resulting bright yellow precipitate was isolated by filtration
washwashed 3 times with boiling ethyl acetate

出典と根拠

ORDレコード: ord-c65d301f6cfb4e26a477c5211e35b32f
出典データセット: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06703402B2

反応ノート

読み込み中…

参加物