Sodium borohydride → 3-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-one

HRID 483050ノート

反応式

HRID 483050 の反応式
[CH3:1][N:2]1[CH2:8][C:6](=[O:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4].[BH4-].[Na+]>CO>[CH3:1][N:2]1[CH2:8][CH:6]([OH:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 130655013-(3,4-Dichlorophenyl)-1-methylimidazolidine-2,4-dione

生成物 1

HCID 133423223-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-one収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
10 °C

実験手順

A 10.4 g (0.04 mole) quantity of 1-methyl-3-(3,4-dichlorophenyl)hydantoin was suspended in 80 ml of methanol. The suspension was cooled to 10° C. and 1.5 g of sodium borohydride was added thereto with stirring. After the addition, the mixture was stirred for 30 minutes and warmed to room temperature, followed by further agitation for 2 hours. After completion of the reaction, the reaction mixture was concentrated and water was added to the residue to deposit crystals. The crystals were filtered and recrystallized from ethanol, affording 9.2 g of white crystals in 88% yield.

後処理

  1. additionAfter the addition
  2. stirringthe mixture was stirred for 30 minutes
  3. temperaturewarmed to room temperature
  4. customAfter completion of the reaction
  5. concentrationthe reaction mixture was concentrated
  6. additionwater was added to the residue to deposit crystals
  7. filtrationThe crystals were filtered
  8. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-ee842a301c4c485abcff6b956cd87ed3
出典データセット
uspto-grants-1986_03
特許番号
US04578107

反応ノート

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