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Methyl 3-aminocrotonate → 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-chloro-3-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 反応物 | 2-(N-Benzyl-N-methylamino)ethyl 3-amino-2-butenoate | HCID 12529188 | — |
| 反応物 | 2-Chloro-3-fluorobenzaldehyde | HCID 14944905 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-chloro-3-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 11755183 | 60.9% |
反応手順
A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04578395 |
| 出典データセット | uspto-grants-1986_03 |
| ORD ID | ord-5f62400733ab4d17b55942c6f710d863 |
| 出典メモ | uspto-grants-1986_03 |