2-Mercaptobenzoic Acid → 2-Styrylsulfanylbenzoic acid

HRID 48323

反応式

HRID 48323 の反応式
C(Br)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([OH:20])(=[O:19])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[SH:14]>C(O)C.[OH-].[Na+]>[CH:2]([S:14][C:13]1[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=1[C:11]([OH:20])=[O:19])=[CH:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 54432-Mercaptobenzoic AcidHCID 98116Bromomethylstyrene

生成物 1

HCID 698934372-Styrylsulfanylbenzoic acid収率 102.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of 1.28 g (6.49 mmol) of cinnamyl bromide in 8 ml of ethanol at room temperature under an atmosphere of nitrogen was added a solution of 1 g (6.49 mmol) of thiosalicylic acid in 5.3 ml of 10% aqueous sodium hydroxide solution. The solution was stirred at room temperature for 16 hours and the solvent then removed under reduced pressure. The residue was dissolved in water and concentrated hydrochloric acid was added. The resultant solid was filtered off and dried. There was obtained 1.7 g of 2-styrylsulfanylbenzoic acid as a white solid, MS: m/e 270 M+.

後処理

  1. customthe solvent then removed under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. additionconcentrated hydrochloric acid was added
  4. filtrationThe resultant solid was filtered off
  5. customdried

出典と根拠

ORDレコード
ord-7a3900057be74659a2b64eb7fa456122
出典データセット
uspto-grants-2004_03
特許番号
US06703387B2

関連ノート

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