Oxalyl chloride → HCID 54425176、化合物

HRID 483311ノート

反応式

HRID 483311 の反応式
[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3]([Cl:13])=[O:4]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 2568962-fluoro-3-methylpentanoic acid

生成物 1

HCID 54425176HCID 54425176、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
40 °C

実験手順

Finally, to the compound (v) was added 10 ml of dichloromethane and then 15 ml of oxalic acid chloride dropwise with ice cooling. The reaction was carried out under reflux at 40° C. for 3 hours. The reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation, and the residues were purified by vacuum distillation. Thus there was obtained 2-fluoro-3-methylpentanoic acid chloride (vi), which has a boiling point of 58°-60° C. (at 20 mmHg).

後処理

  1. distillationThe reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation
  2. distillationthe residues were purified by vacuum distillation

出典と根拠

ORDレコード
ord-da6bdb019bbd4e6081af3d78a728ff6c
出典データセット
uspto-grants-1993_07
特許番号
US05225105

反応ノート

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