5-Methylthiazole → 5-Methyl-3-[[3-[[4-(tetradecyloxy)benzoyl]amino]phenyl]methyl]thiazolium bromide

HRID 483562ノート

反応式

HRID 483562 の反応式
[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:32])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=2)[CH:6]=[CH:7][CH:8]=1.[CH3:33][C:34]1[S:38][CH:37]=[N:36][CH:35]=1>C1(C)C=CC=CC=1>[Br-:1].[CH3:33][C:34]1[S:38][CH:37]=[N+:36]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][C:10](=[O:32])[C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][CH:12]=3)[CH:4]=2)[CH:35]=1

参加物

4

反応物 2

HCID 1379805-MethylthiazoleHCID 11755784N-[3-(Bromomethyl)phenyl]-4-(tetradecyloxy)benzamide

生成物 1

HCID 101001345-Methyl-3-[[3-[[4-(tetradecyloxy)benzoyl]amino]phenyl]methyl]thiazolium bromide収率 91.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 4 g of N-[3-(bromomethyl) phenyl]-4-(tetradecyloxy)benzamide and 3.95 g of 5-methylthiazole in 50 ml of toluene is refluxed under argon for 4 hours. The solvent is removed and ether added to the residue. The solid is collected by centrifugation and washed several times with ether then vacuum dried to give 4.4 g of the desired product as a white powder, m.p. 188°-192° C.

後処理

  1. temperatureis refluxed under argon for 4 hours
  2. customThe solvent is removed
  3. additionether added to the residue
  4. customThe solid is collected by centrifugation
  5. washwashed several times with ether
  6. customvacuum dried

出典と根拠

ORDレコード
ord-e6b7b0303b6a4438af337e2f4c620249
出典データセット
uspto-grants-1993_07
特許番号
US05225425

反応ノート

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