5-Methylthiazole → 3-[[3-[Acetyl[[4-(tetradecyloxy)phenyl]methyl]amino]phenyl]methyl]-5-methylthiazolium bromide

HRID 483565

反応式

HRID 483565 の反応式
[Br:1][CH2:2][C:3]1[CH:4]=[C:5]([N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:16][CH:15]=2)[C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1.[CH3:35][C:36]1[S:40][CH:39]=[N:38][CH:37]=1>C1(C)C=CC=CC=1.CCOCC>[Br-:1].[C:10]([N:9]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:16][CH:15]=1)[C:5]1[CH:4]=[C:3]([CH2:2][N+:38]2[CH:37]=[C:36]([CH3:35])[S:40][CH:39]=2)[CH:8]=[CH:7][CH:6]=1)(=[O:12])[CH3:11]

参加物

5

反応物 2

HCID 1379805-MethylthiazoleHCID 10414650N-[3-(bromomethyl)phenyl]-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide

生成物 1

HCID 103718203-[[3-[Acetyl[[4-(tetradecyloxy)phenyl]methyl]amino]phenyl]methyl]-5-methylthiazolium bromide収率 87.1%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 3 g of N-[3-(bromomethyl)phenyl]-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide and 2.24 g of 5-methylthiazole in 40 ml of toluene is refluxed for 4 hours, cooled and diluted with 60 ml of ether and allowed to stand at room temperature overnight. The solid is collected by centrifugation and washed three times with ether then vacuum dried to give 3.1 g of the desired product as a white powder, m.p. 130°-134° C.

後処理

  1. temperatureis refluxed for 4 hours
  2. temperaturecooled
  3. customThe solid is collected by centrifugation
  4. washwashed three times with ether
  5. customvacuum dried

出典と根拠

ORDレコード
ord-b4f05f7986e84ce2b9c66cc09b327cd0
出典データセット
uspto-grants-1993_07
特許番号
US05225425

関連ノート

読み込み中…