Water → 3-Benzyl-4-fluorobenzyl alcohol

HRID 483741ノート

反応式

HRID 483741 の反応式
[CH2:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[F:16])[CH:11]=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].O.C(OCC)C>CO>[CH2:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][C:15]=1[F:16])[CH2:11][OH:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 4311764Sodium borohydrideHCID 138542803-Benzyl-4-fluorobenzaldehyde

生成物 1

HCID 138542813-Benzyl-4-fluorobenzyl alcohol収率 79.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 3-benzyl-4-fluorobenzaldehyde (5 g) in methanol (75 cm3) was cooled to 0° C. Sodium borohydride (1.34 g) was added in portions, and the mixture stirred for 1 hour. The reaction mixture was then poured cautiously into a mixture of water and diethyl ether, and the organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulphate. Evaporation of the solvents under reduced pressure gave a pale yellow oil which was purified by distillation in a kugelrohr apparatus to give 3-benzyl-4-fluorobenzyl alcohol (4.0 g).

後処理

  1. customthe organic layer was separated
  2. washwashed with water and brine
  3. dry with materialdried over anhydrous magnesium sulphate
  4. customEvaporation of the solvents under reduced pressure
  5. customgave a pale yellow oil which
  6. distillationwas purified by distillation in a kugelrohr apparatus

出典と根拠

ORDレコード
ord-0ce8d2904ac845a6af28424fb246a16f
出典データセット
uspto-grants-1993_07
特許番号
US05225607

反応ノート

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