反応式
Br[C:2]1[CH:7]=[C:6]([F:8])[C:5](Br)=[CH:4][C:3]=1[F:10].C([Sn](CCCC)(CCCC)C([O:18][CH2:19][CH3:20])=C)CCC.C1C[O:32][CH2:31][CH2:30]1>>[C:31]([C:5]1[C:6]([F:8])=[CH:7][C:2]([C:19](=[O:18])[CH3:20])=[C:3]([F:10])[CH:4]=1)(=[O:32])[CH3:30]参加物
4
実験手順
1,4-dibromo-2,5-Difluorobenzene (2.5 g, 9.2 mmol), dichlorobis(triphenylphosphine) palladium (II) (0.645 g, 0.92 mmol), tributyl-(1-ethoxyvinyl)tin (10 g, 27.7 mmol), and THF (50 mL) were combined in a manner analogous to the procedure described in example 14 to provide the intermediate title compound, 1-(4-acetyl-2,5-difluorophenyl)ethan-1-one, (1.8 g, 100%) as a white crystal. Electron spray M.S. 197.9 (M*−H).
出典と根拠
- ORDレコード
- ord-b6ab73d220ea4989b969bf0cfabfe402
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703425B2
関連ノート
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