Water → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

HRID 48397

反応式

HRID 48397 の反応式
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](OC(=O)C)(=[O:13])[CH3:12].O>N1C=CC=CC=1>[C:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:13])[CH3:12]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 763102-Aminoindane

生成物 1

HCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide収率 71.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-aminoindan (6.0 g, 45 mmol) was dissolved in dry pyridine (7 ml), to which acetic anhydride (4.5 ml, 47.3 mmol) was added dropwise while cooling in ice water. After the reaction mixture was returned to room temperature and stirred for 20 minutes, water was added. The precipitate that deposited was filtered to obtain 2-acetamidoindan (5.6 g, 32 mmol).

後処理

  1. additionwas added dropwise
  2. customwas returned to room temperature
  3. filtrationThe precipitate that deposited was filtered

出典と根拠

ORDレコード
ord-98d057ea4c4f49e8bf8e66ae144e62ee
出典データセット
uspto-grants-2004_03
特許番号
US06703421B1

関連ノート

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