Potassium Carbonate → 1-(2-Benzothiazolyl)-4-piperidinemethanol

HRID 484060ノート

反応式

HRID 484060 の反応式
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl[C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 119872-ChlorobenzothiazoleHCID 4207714-Piperidinemethanol

生成物 1

HCID 197495981-(2-Benzothiazolyl)-4-piperidinemethanol

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

30 g of 4-hydroxymethylpiperidine, 44 g of 2-chlorobenzothiazole and 72 g of potassium carbonate are reacted in 600 ml of acetonitrile under reflux overnight. After filtration and evaporation of the solvent, the residue is taken up in 200 ml of ethyl acetate and extracted with 1N hydrochloric acid. The aqueous phase is made alkaline with caustic soda and extracted with dichloromethane. The expected product is obtained by drying and evaporation.

後処理

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration and evaporation of the solvent
  3. extractionextracted with 1N hydrochloric acid
  4. extractionextracted with dichloromethane

出典と根拠

ORDレコード
ord-dbea2f4798a04c9585a5415e578b8940
出典データセット
uspto-grants-1993_07
特許番号
US05229398

反応ノート

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