Phosphorus tribromide → (5-Bromopentyl)benzene

HRID 484337

反応式

HRID 484337 の反応式
P(Br)(Br)[Br:2].[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]O)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(Cl)(Cl)Cl>[C:5]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][Br:2])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromide2 回HCID 615235-Phenyl-1-pentanol

生成物 1

HCID 285561(5-Bromopentyl)benzene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A 1.8 g (6.7 mmol) amount of phosphorus tribromide was added to a chloroform solution (20 ml) of 3.3 g (20 mmol) of 5-phenyl-1-pentanol and the resulting solution was heated at reflux for 4 hours. When the reaction was traced by TLC, the starting materials were found to still remain in the reaction mixture, and so 0.2 g of phosphorus tribromide was further added and heated at reflux. Afterwards, the reaction solution was washed with water and dried with anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. Thus, 4.30 g of a crude 5-phenylpentyl bromide was obtained.

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 4 hours
  3. additionwas further added
  4. temperatureheated
  5. temperatureat reflux
  6. washAfterwards, the reaction solution was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-37c2e7860e4e4a2284712f3d40aed8d0
出典データセット
uspto-grants-1993_07
特許番号
US05231105

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