Phenyl isocyanate → HCID 15049043、化合物

HRID 484553ノート

反応式

HRID 484553 の反応式
[Cl-].[C:2]([CH2:5][O:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]1[NH3+:13])([OH:4])=[O:3].[C:14]1([N:20]=[C:21]=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>[OH-].[Na+]>[C:14]1([NH:20][C:21](=[O:22])[NH:13][C@@H:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C@H:7]2[O:6][CH2:5][C:2]([OH:4])=[O:3])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 7672Phenyl isocyanateHCID 67747384HCID 67747384、化合物

生成物 1

HCID 15049043HCID 15049043、化合物収率 40%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of trans-2-carboxymethoxy-cyclohexyl ammonium chloride (0.419 g, 2 mmoles) in 2N NaOH (10 ml), phenylisocyanate (0.476 g, 4 mmoles) was added under stirring. After 1 hour the solution was extracted with diethyl ether (10 ml) and the aqueous phase was acidified with HCl 18% to pH 3. The title compound separated in the form of white crystals, which were filtered off and dried over P2O5. Thus, there were obtained 0.23 g (40%) of the title compound, melting point 166°-168° C.

後処理

  1. extractionAfter 1 hour the solution was extracted with diethyl ether (10 ml)
  2. customThe title compound separated in the form of white crystals, which
  3. filtrationwere filtered off
  4. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-6aec0ad471b44907b25d4bb1fb1ed602
出典データセット
uspto-grants-1993_07
特許番号
US05231216

反応ノート

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