Hydrogen Bromide → 4-(1-ethyl-1H-imidazol-2-yl)phenol
反応式
Cl.[CH2:2]([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=1)[CH3:3].Br>C(O)(=O)C>[CH2:2]([N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[CH3:3]参加物
4
実験手順
A mixture of 7 parts of 1-ethyl-2-(4-methoxyphenyl)-1H-imidazole monohydrochloride and 75 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and a refluxed for 2 hours. The reaction mixture is concentrated and a small amount of water is added to the concentrate. The whole is neutralized with sodium hydrogen carbonate. The precipitated product is filtered off and crystallized from a mixture of ethanol and water, yielding 3.3 parts of 4-(1-ethyl-1H-imidazol-2-yl)phenol.
後処理
- temperaturea refluxed for 2 hours
- concentrationThe reaction mixture is concentrated
- additiona small amount of water is added to the concentrate
- filtrationThe precipitated product is filtered off
- customcrystallized from a mixture of ethanol and water
出典と根拠
- ORDレコード
- ord-1384605fa118448aa3eeade454131964
- 出典データセット
- uspto-grants-1985_08
- 特許番号
- US04533550
反応ノート
読み込み中…