Hydrogen Bromide → 6-(2-bromoethyl)-2,3,7-trimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one monohydrobromide
反応式
O[CH2:2][CH2:3][C:4]1[C:5](=[O:17])[NH:6][C:7]([S:11][CH:12]([CH3:16])[C:13](=O)[CH3:14])=[N:8][C:9]=1[CH3:10].[BrH:18]>C(O)(=O)C>[BrH:18].[Br:18][CH2:2][CH2:3][C:4]1[C:5](=[O:17])[N:6]2[C:13]([CH3:14])=[C:12]([CH3:16])[S:11][C:7]2=[N:8][C:9]=1[CH3:10]参加物
4
反応条件
- 温度
- 90 °C
実験手順
A mixture of 36 parts of 5-(2-hydroxyethyl)-6-methyl-2-[(1-methyl-2-oxopropyl)thio]-4(3H)-pyrimidinone and 240 parts of a hydrobromic acid solution 60% in acetic acid was stirred and heated for 4 hours at 90° C. The reaction mixture was evaporated and the residue was suspended in 400 parts of 2-propanone. The solid product was filtered off, washed with 2-propanone and dried, yielding 44 parts of 6-(2-bromoethyl)-2,3,7-trimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one monohydrobromide; m.p. 172° C. (intermediate 7).