Hydrochloric Acid → N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide

HRID 484783ノート

反応式

HRID 484783 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.Cl>N1C=CC=CC=1>[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16]([NH:4][C:3]2[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:2]=2[CH3:1])(=[O:18])=[O:17])=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 68962,6-DimethylanilineHCID 73974-Toluenesulfonyl chloride

生成物 1

HCID 262999N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide収率 136.2%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 23.4 g (0.12 mole) of 2,6-dimethylaniline and 40.5 g (0.19 mole) of p-toluenesulfonyl chloride in 75 ml of pyridine was heated at reflux for three hours. The mixture was cooled and poured into vigorously stirred 2N hydrochloric acid. The crude product was recrystallized from ethanol to give 45 g of the title compound. Structure assignment was supported by the nmr spectrum and by elemental analysis.

後処理

  1. temperatureat reflux for three hours
  2. temperatureThe mixture was cooled
  3. customThe crude product was recrystallized from ethanol

出典と根拠

ORDレコード
ord-795c7189b36c44c7b08a9d3db755d75c
出典データセット
uspto-grants-1985_08
特許番号
US04533739

反応ノート

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