Hydrochloric Acid → 2-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

HRID 484786ノート

反応式

HRID 484786 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1.[ClH:17]>C(O)C.[Pd]>[ClH:17].[ClH:17].[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 13520142N-(2-Methyl-4-nitrophenyl)-3,4-dihydro-2H-pyrrol-5-amine

生成物 1

HCID 1317142942-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The product compound of Example 8 was dissolved in 1.2 liter of ethanol containing 53.4 ml of concentrated hydrochloric acid and hydrogenated at 2 psi over 5% palladium on carbon. After removal of catalyst by filtration, the filtrate was concentrated in vacuo to give 85 g of the title compound. Structure assignment was supported by the nmr spectrum and by elemental analysis.

後処理

  1. customAfter removal of catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-7b907801ad1e442e9344b86ae0bea55e
出典データセット
uspto-grants-1985_08
特許番号
US04533739

反応ノート

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