Dimethylamine → 1-Methyl-3-phenoxypropyldimethylamine

HRID 484836ノート

反応式

HRID 484836 の反応式
CO.S(C1C=CC(C)=CC=1)(O[CH:7]([CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:8])(=O)=O.[CH3:25][NH:26][CH3:27].C(OCC)C>C(Cl)(Cl)Cl>[CH3:8][CH:7]([N:26]([CH3:27])[CH3:25])[CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 674DimethylamineHCID 887MethanolHCID 3283Diethyl EtherHCID 133267624-Phenoxy-2-butyl tosylate

生成物 1

HCID 201358801-Methyl-3-phenoxypropyldimethylamine収率 66%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To 60 ml of absolute methyl alcohol were added 10 g of 4-phenoxy-2-butyl tosylate and 5.93 g of dimethylamine. The mixture was reacted in a sealed tube for one hour at 125° C. After the reaction solution was condensed under reduced pressure, 100 ml of diethyl ether was added into the solution and the solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution. The ether layer was dried over anhydrous sodium sulfate, and then the ether was removed under reduced pressure therefrom. The residue thus obtained was subjected to an alumina-column chromatography using chloroform as the developing solvent to give 3.98 g of 1-methyl-3-phenoxypropyldimethylamine in a yield of 66%.

後処理

  1. customThe mixture was reacted in a sealed tube for one hour at 125° C
  2. additionwas added into the solution
  3. customthe solution was separated into the diethyl ether solution and 20% aqueous sodium hydroxide solution
  4. dry with materialThe ether layer was dried over anhydrous sodium sulfate
  5. customthe ether was removed under reduced pressure
  6. customThe residue thus obtained

出典と根拠

ORDレコード
ord-3be2d2278064467d80d6824ce1253988
出典データセット
uspto-grants-1985_08
特許番号
US04533731

反応ノート

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