Diethyl Ether → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 484841ノート

反応式

HRID 484841 の反応式
O1CCOCC1.[NH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1.[C:17]1(=O)[O:22][C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.C(OCC)C>O>[C:17]1(=[O:22])[N:7]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)[C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 6811Phthalic AnhydrideHCID 133991H-indazol-3-amineHCID 312751,4-Dioxane

生成物 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 50 ml of dioxane were added 5.0 g of 3-aminoindazole thus obtained and 6.68 g of phthalic anhydride, and the mixture was stirred for 5 hours at 120° C. After the mixture was condensed under reduced pressure, the condensed residue was added with 30 ml of diethyl ether and stirred under cooling with ice and water for 30 minutes to separate crystals. Then the crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole having the following analytical values in a yield of 87%.

後処理

  1. customthus obtained
  2. customcondensed under reduced pressure
  3. customto separate crystals
  4. customThen the crystals were obtained by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-bfae535ec8954489b8808c2a0ebed39f
出典データセット
uspto-grants-1985_08
特許番号
US04533731

反応ノート

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