Nitric Acid → Methyl 2-bromo-4-fluoro-5-nitrophenoxyformate
反応式
[Br:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[O:4][C:5]([O:7][CH3:8])=[O:6].[N+:14]([O-])([OH:16])=[O:15]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[O:4][C:5]([O:7][CH3:8])=[O:6]参加物
4
実験手順
Then, 110 g (0.44 mol) of methyl 2-bromo-4-fluorophenoxyformate was dissolved in 250 ml of sulfuric acid, to which a mixed acid of 30 g of fuming nitric acid and 30 ml of sulfuric acid was added dropwise at 5° C. or lower, and the mixture was stirred for 2 hours. The reaction mixture was poured onto ice, and the precipitated crystals were collected by filtration, washed with water, and dried, which afforded 126 g (0.43 mol) of methyl 2-bromo-4-fluoro-5-nitrophenoxyformate.
後処理
- additionwas added dropwise at 5° C.
- additionThe reaction mixture was poured onto ice
- filtrationthe precipitated crystals were collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0f13797f74d449c092f060ea899a8952
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703503B2
反応ノート
読み込み中…