Sodium Hydroxide → 2-Bromo-4-fluoro-5-nitrophenol
反応式
[Br:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[O:4]C(OC)=O.[OH-].[Na+]>O>[Br:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[OH:4]参加物
4
実験手順
Then, 125 g (0.43 mol) of methyl 2-bromo-4-fluoro-5-nitrophenoxyformate was suspended in 200 ml of water, to which 19 g (0.47 mol) of sodium hydroxide was added, and the mixture was stirred at 50° to 60° C. for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and washed with chloroform. The aqueous layer was acidified with aqueous hydrochloric acid and extracted with ethyl acetate. The ethyl acetate layer was dried and concentrated, which afforded 104 g (0.43 mol) of 2-bromo-4-fluoro-5-nitrophenol.
後処理
- additionwas added
- customAfter completion of the reaction
- washwashed with chloroform
- extractionextracted with ethyl acetate
- dry with materialThe ethyl acetate layer was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-3957061fae814674a25c6e9028b15568
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703503B2
反応ノート
読み込み中…