Ethyl bromoacetate → HCID 20271337、化合物

反応式

[F:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([NH:8][CH2:9][C:10](=[O:15])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:7])=[CH:4][CH:3]=1.[OH-].[K+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>CS(C)=O>[F:1][C:2]1[CH:17]=[CH:16][C:5]([C:6]([NH:8][CH:9]([C:10](=[O:15])[CH2:11][CH:12]([CH3:14])[CH3:13])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[O:7])=[CH:4][CH:3]=1

参加物

実験手順

4.0 g of N-(4-fluorobenzoyl)isovalerylmethylamine are dissolved in 20 ml of dimethylsulfoxide and 1.3 g of potassium hydroxide are added thereto at 5° C. to 10° C. under vigorous stirring. The mixture is further stirred for 10 minutes. 3.1 g of ethyl bromoacetate are added dropwise to the mixture at the same temperature, and said mixture is further stirred for 2 hours. After the reaction, the mixture is treated in the same manner as described in Preparation 1-(5). 3.5 g of ethyl 3-(4-fluorobenzoylamino)-3-isovalerylpropionate are thereby obtained as oil. Yield: 64.8%.