Sodium Hydroxide → Tucaresol

HRID 485164

反応式

HRID 485164 の反応式
[CH:1]([C:3]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][C:4]=1[O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1)=[O:2].[OH-].[Na+]>C(O)C.O>[CH:1]([C:3]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][C:4]=1[O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1)=[O:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 9861133Ethyl 4-(2-formyl-3-hydroxyphenoxymethyl)benzoate

生成物 1

HCID 55223Tucaresol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Ethyl 4-(2-formyl-3-hydroxyphenoxymethyl)benzoate (0.6 g. 0.002 M) was suspended in 95% ethanol (5 ml) and 1 N sodium hydroxide solution (5 ml) and stirred at room temperature (2.5 hr). The yellow solution was diluted with water, extracted with ethyl acetate, and acidified with concentrated hydrochloric acid. The precipitated solid was filtered off, washed well with water, and recrystallised from 95% ethanol to give 4-(2-formyl-3-hydroxyphenoxymethyl) benzoic acid, m.p. 239°-240° C. (Found: C. 65.99; H, 4.29. C15H12O5 requires C, 66.17; H, 4.44%).

後処理

  1. extractionextracted with ethyl acetate
  2. filtrationThe precipitated solid was filtered off
  3. washwashed well with water
  4. customrecrystallised from 95% ethanol

出典と根拠

ORDレコード
ord-ff35f5f0f91c472d83d1af4b07930a86
出典データセット
uspto-grants-1985_08
特許番号
US04535183

関連ノート

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