3-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole → 3-(2-carboxyethyl)-N-(3-pyridyl)indole

HRID 485338ノート

反応式

HRID 485338 の反応式
C([O:3][C:4]([CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)=[O:5])C>CO.[OH-].[Na+]>[C:4]([CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)([OH:5])=[O:3]

参加物

4

反応物 1

HCID 202701823-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole

生成物 1

HCID 134903533-(2-carboxyethyl)-N-(3-pyridyl)indole

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 2.0 g of 3-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole in 10 ml of methanol and 10 ml of 1N sodium hydroxide is refluxed for two hours, cooled, and evaporated. The residue is taken up in 10 ml of water, extracted with 10 ml of ether and adjusted to pH=6 with concentrated sulfuric acid. The resulting solid is filtered and dried to yield 3-(2-carboxyethyl)-N-(3-pyridyl)indole, m.p. 147°-149°.

後処理

  1. temperaturecooled
  2. customevaporated
  3. extractionextracted with 10 ml of ether
  4. filtrationThe resulting solid is filtered
  5. customdried

出典と根拠

ORDレコード
ord-ee34d8fe9f954488bb4d46a25f795861
出典データセット
uspto-grants-1985_08
特許番号
US04536505

反応ノート

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