Sodium Hydroxide → 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole

HRID 485348ノート

反応式

HRID 485348 の反応式
C([O:3][C:4]([C:6]([CH3:23])=[CH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)=[O:5])C.[OH-].[Na+]>CO.O>[C:4]([C:6]([CH3:23])=[CH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)([OH:5])=[O:3]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 539181563-[2-(ethoxycarbonyl)prop-1-enyl]-N-(3-pyridyl)indole

生成物 1

HCID 545426033-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of 1.1 g of 3-[2-(ethoxycarbonyl)-prop-1-enyl)-N-(3-pyridyl)indole, and 0.288 g of sodium hydroxide in 10 ml of methanol and 10 ml of water is heated under reflux for 2 hours, cooled and evaporated. The resulting oil is redissolved in 10 ml of ice water and is neutralized with 0.59 ml of concentrated hydrochloric acid. The resulting solid is filtered and dried to yield 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole, m.p. 213°-215°.

後処理

  1. temperatureunder reflux for 2 hours
  2. temperaturecooled
  3. customevaporated
  4. dissolutionThe resulting oil is redissolved in 10 ml of ice water
  5. filtrationThe resulting solid is filtered
  6. customdried

出典と根拠

ORDレコード
ord-7fda04becbe44a579bd74c36533edeea
出典データセット
uspto-grants-1985_08
特許番号
US04536505

反応ノート

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