Hydrochloric Acid → Dibenzo[b,f]thiepin-3-carboxylic Acid 5-Oxide

反応式

[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:12]=[CH:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[S:8](=[O:17])[C:7]=2[CH:18]=1)#N.[OH-:19].[Na+].Cl.[OH2:22]>>[CH:5]1[C:6]2[CH:12]=[CH:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[S:8](=[O:17])[C:7]=2[CH:18]=[C:3]([C:1]([OH:22])=[O:19])[CH:4]=1

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 962Water

HCID 14798Sodium Hydroxide

HCID 131518733-Cyanodibenzo[b,f]thiepin 5-oxide

生成物 1

HCID 13151872Dibenzo[b,f]thiepin-3-carboxylic Acid 5-Oxide

実験手順

925 Mg. 3-cyanodibenzo[b,f]thiepin 5-oxide are refluxed for 31/2 hours in a mixture of 60 cc. 10% aqueous sodium hydroxide solution and 60 cc. denatured alcohol. The mixture is diluted with 1/2 liter of water and acidified with concentrated HCl. The acid precipitates and is filtered and dried. The yield of white dibenzo[b,f]thiepin-3-carboxylic acid 5-oxide is 965 mg. (97%), m.p. dec. 249° C.