Thionyl Chloride → 3-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f]thiepin
反応式
[O:1]=[C:2]1[CH2:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[S:5][C:4]2[CH:13]=[C:14]([C:17]([OH:19])=O)[CH:15]=[CH:16][C:3]1=2.S(Cl)([Cl:22])=O>>[Cl:22][C:17]([C:14]1[CH:15]=[CH:16][C:3]2[C:2](=[O:1])[CH2:8][C:7]3[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=3[S:5][C:4]=2[CH:13]=1)=[O:19]参加物
3
実験手順
Heat a solution of 5 g. of 10,11-dihydro-11-oxodibenzo[b,f]thiepin-3-carboxylic acid and 40 ml. of thionyl chloride under reflux for 20 minutes. Evaporate the reaction mixture under vacuum to dryness. Repeat the evaporation with two 30 ml. portions of carbon tetrachloride. Crystallize the residue from diisopropyl ether to obtain the title product.
後処理
- temperatureHeat a solution of 5 g
- customEvaporate the reaction mixture under vacuum to dryness
- customRepeat the evaporation with two 30 ml
- customCrystallize the residue from diisopropyl ether
出典と根拠
- ORDレコード
- ord-637704ddc69f4fdd90fe66eab68e6054
- 出典データセット
- uspto-grants-1985_08
- 特許番号
- US04536507
反応ノート
読み込み中…