N-bromobutanimide → 2-bromo-1-bromomethyl-3-nitrobenzene

HRID 485562

反応式

HRID 485562 の反応式
[Br:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:11].[Br:12]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:11][Br:12]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 2318282-Bromo-3-nitrotoluene

生成物 1

HCID 110663422-bromo-1-bromomethyl-3-nitrobenzene収率 90.4%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A stirred solution of 1-bromo-2-methyl-6-nitrobenzene (16.2 g, 0.075 mole) in 200 ml of carbon tetrachloride was irradiated and heated at reflux with a 250 watt brooder lamp. N-bromosuccinimide (13.5 g, 0.075 mole) was added to the refluxing reaction mixture, and the mixture was stirred for approximately 23 hours. The mixture was cooled, filtered, and washed with two 200 ml portions of saturated aqueous sodium chloride solution. The organic phase was passed through phase separation filter paper. The filtrate was evaporated under reduced pressure to give 2-bromo-1-bromomethyl-3-nitrobenzene (20 g).

後処理

  1. temperatureheated
  2. temperatureat reflux with a 250 watt brooder lamp
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. washwashed with two 200 ml portions of saturated aqueous sodium chloride solution
  6. customThe organic phase was passed through phase separation
  7. filtrationfilter paper
  8. customThe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e748fb93d32148a7a0fee7927360b558
出典データセット
uspto-grants-1985_08
特許番号
US04536591

関連ノート

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