2,3,4,5,6,7-Hexahydro-1H-1-benzazonine-2,7-dione → 7-Hydroxy-1,3,4,5,6,7-hexahydro-2H-1-benzazonin-2-one

HRID 485665ノート

反応式

HRID 485665 の反応式
[NH:1]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=[O:15].[BH4-].[Na+]>C(O)C>[OH:14][CH:7]1[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:1][C:2](=[O:15])[CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 5775412,3,4,5,6,7-Hexahydro-1H-1-benzazonine-2,7-dioneHCID 4311764Sodium borohydride

生成物 1

HCID 133387277-Hydroxy-1,3,4,5,6,7-hexahydro-2H-1-benzazonin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3,4,5,6-tetrahydro-1H-1-benzazonin-2,7-dione (14.2 g), J. Am. Chem. Soc. 88, 1049 (1966), and sodium borohydride (1.4 g) in ethanol (720 ml) is stirred at room temperature for 18 hours. The ethanol is removed under reduced pressure, and the residue dissolved in dichloromethane (350 ml). The solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml), and dried over sodium sulfate. The solvent is removed under reduced pressure to give 7-hydroxy-1,3,4,5,6,7-hexahydro-1-benzazonin-2-one.

後処理

  1. customThe ethanol is removed under reduced pressure
  2. dissolutionthe residue dissolved in dichloromethane (350 ml)
  3. extractionThe solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml)
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-0b72ee6ecc1545848586c964a8d265b2
出典データセット
uspto-grants-1985_08
特許番号
US04537885

反応ノート

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