Hydrochloric Acid → 1-phenyl-1H-pyrazol-5-ol

HRID 485680ノート

反応式

HRID 485680 の反応式
C(OC([C:6]1[C:10](=[O:11])[N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[NH:8][CH:7]=1)=O)C.Cl>[OH-].[Na+]>[C:12]1([N:9]2[C:10](=[O:11])[CH:6]=[CH:7][NH:8]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 223722Ethyl 3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxylate

生成物 1

HCID 27487101-phenyl-1H-pyrazol-5-ol収率 72.7%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

4-Ethoxycarbonyl-1-phenyl-3-pyrazolin-5-one (2.139 g, 9.2 mmol) in 1N sodium hydroxide (50 ml) was stirred under nitrogen at vigorous reflux for three hours. The reaction mixture was allowed to cool and acidified (HCl) to pH 3.5, whereupon ethyl acetate extraction, followed by drying (MgSO4) and evaporation produced the desired product (1.072 g, 72%) δ max(CHCl3) 1705, 1595, 1495 cm-1 δ(D6 -DMSO) 5.60 (1H,d,J2 Hz, C4 proton), 7.60 (6H, m, phenyl protons and C3 proton) Found; M+ ; 160.0641. C9H8N2O6 requires M; 160.0637.

後処理

  1. temperatureat vigorous reflux for three hours
  2. temperatureto cool
  3. extractionwhereupon ethyl acetate extraction
  4. customby drying
  5. custom(MgSO4) and evaporation

出典と根拠

ORDレコード
ord-e552ae1ab9a741ab8e60d2c0b06aecd9
出典データセット
uspto-grants-1985_08
特許番号
US04537886

反応ノート

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