HCID 178482203、化合物 → HCID 178482196、化合物

HRID 485753ノート

反応式

HRID 485753 の反応式
[CH3:1][NH:2][C:3]1[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][C:4]=1[C:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([OH:16])=[N:8]1)=[O:6]>CCO.[Pd]>[CH3:1][NH:2][C:3]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][C:4]=1[C:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([OH:16])=[N:8]1)=[O:6]

参加物

4

反応物 1

HCID 178482203HCID 178482203、化合物

生成物 1

HCID 178482196HCID 178482196、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To 1.1 g. of 1-(2-methylamino-5-nitrobenzoyl)-1H-indazol-3-ol, prepared in Example 14, suspended in 200 ml of absolute EtOH was added 200 mg of 5% Pd/C and the mixture was hydrogenated at 50 psi for 16 hours. The catalyst was filtered off, washed with hot EtOH and the filtrate was diluted with H2O and concentrated to small volume. The precipitate was collected, washed with cold 95% EtOH and dried; yield of dark-yellow amorphous powder 0.65 g. (65.4%); m.p. 184°-186° C.

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with hot EtOH
  3. additionthe filtrate was diluted with H2O
  4. concentrationconcentrated to small volume
  5. customThe precipitate was collected
  6. washwashed with cold 95% EtOH
  7. customdried

出典と根拠

ORDレコード
ord-2e1ea073a0d54675ae6a193630976836
出典データセット
uspto-grants-1985_08
特許番号
US04537966

反応ノート

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