L-Leucine → N-(3,5-dinitrobenzoyl)leucine

HRID 485977

反応式

HRID 485977 の反応式
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[N+:10]([C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([N+:22]([O-:24])=[O:23])[CH:21]=1)[C:16](Cl)=[O:17])([O-:12])=[O:11].C1OC1C>O1CCCC1>[N+:10]([C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([N+:22]([O-:24])=[O:23])[CH:21]=1)[C:16]([NH:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:17])([O-:12])=[O:11]

参加物

5

反応物 3

HCID 6106L-LeucineHCID 6378Propylene OxideHCID 74323,5-Dinitrobenzoyl chloride2 回

生成物 1

HCID 101111N-(3,5-dinitrobenzoyl)leucine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(S)-Leucine (10 g) was suspended in 150 mL dry tetrahydrofuran and chilled in an ice bath while stirring under a nitrogen atmosphere. 3,5-Dinitrobenzoyl chloride (Table 2, Compound 13, 21 g) and propylene oxide (6.6 g) were added; the resulting heterogeneous mixture became clear after several minutes. The mixture was allowed to stir for 5 h, and was evaporated under reduced pressure to afford an oil which crystallized upon addition of 100 mL of cold dichloromethane. Filtration and drying of the resulting crystals afforded 3,5-dinitrobenzoyl-(S)-leucine, 14, as a white solid (20.64 g, 83% yield). 1H NMR (200 MHz, d6DMSO) δ: 0.95 (m,6 H), 1.75 (M,3 H), 4.25 (m,1 H), 9.00 (t,1 H), 9.17 (d,2 H), 9.41 (d,1 H).

後処理

  1. temperaturechilled in an ice bath
  2. waitthe resulting heterogeneous mixture became clear after several minutes
  3. stirringto stir for 5 h
  4. customwas evaporated under reduced pressure
  5. customto afford an oil which
  6. customcrystallized upon addition of 100 mL of cold dichloromethane
  7. filtrationFiltration
  8. customdrying of the resulting crystals

出典と根拠

ORDレコード
ord-385eb14be42147ada7d63050fbe69141
出典データセット
uspto-grants-1994_03
特許番号
US05290440

関連ノート

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