Water → 2-(6-Methoxynaphthalen-2-yl)propanenitrile

HRID 485979

反応式

HRID 485979 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([NH2:16])=O)[CH:7]=[CH:6]2.FC(F)(F)C(OC(=O)C(F)(F)F)=O.O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]#[N:16])[CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 962WaterHCID 9845Trifluoroacetic anhydrideHCID 6040272-(6-Methoxy-2-naphthyl)propanamide

生成物 1

HCID 6073442-(6-Methoxynaphthalen-2-yl)propanenitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In 50 ml of dry THF, were suspended 3.0 g of oa (6-methoxy-2-naphthyl)-propanamide, followed by adding thereto 8.3 g of trifluoroacetic anhydride and then stirring at room temperature for 12 hours. The resulting reaction mixture was poured into 200 ml of iced water, and then precipitated white solid was filtered off. After purifying with silica gel column, the product was recrystallized twice with ethanol to obtain 2.1 g of oa (6-methoxy-2-naphthyl)propanonitrile (Compound No. 1-1) of this invention.

後処理

  1. additionby adding
  2. customThe resulting reaction mixture
  3. customprecipitated white solid
  4. filtrationwas filtered off
  5. customAfter purifying with silica gel column
  6. customthe product was recrystallized twice with ethanol

出典と根拠

ORDレコード
ord-177fe75a398b49d0b22efabee0342176
出典データセット
uspto-grants-1994_03
特許番号
US05290478

関連ノート

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