HCID 178418443、化合物 → HCID 178441859、化合物

HRID 486021ノート

反応式

HRID 486021 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([CH:16]=[O:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[CH2:18]([Mg]Br)[CH3:19]>O1CCCC1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([CH:16]([OH:17])[CH2:18][CH3:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 178418443HCID 178418443、化合物HCID 178441857HCID 178441857、化合物

生成物 1

HCID 178441859HCID 178441859、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of 0.25 g of 2-butyl-1,4-dihydro-4-oxo-6-quinazoline-carboxaldehyde in 10 ml of dry tetrahydrofuran, cooled to 0° C., is added 1.63 ml of 2.0M ethyl magnesium bromide in tetrahydrofuran. The reaction mixture is stirred for 30 minutes at 0° C. and quenched with 20 ml of saturated ammonium chloride solution and 20 ml of water. The reaction mixture is extracted with 9:1 chloroform-methanol, dried over magnesium sulfate, filtered and evaporated in vacuo to give 0.26 g of the desired product. CI MASS SPEC 261(MH+).

後処理

  1. customquenched with 20 ml of saturated ammonium chloride solution and 20 ml of water
  2. extractionThe reaction mixture is extracted with 9:1 chloroform-methanol
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-6f851d23bf3949f1b4f715af050f42b0
出典データセット
uspto-grants-1994_03
特許番号
US05290780

反応ノート

読み込み中…