Sodium borohydride → HCID 178441847、化合物

HRID 486025ノート

反応式

HRID 486025 の反応式
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9]([CH2:14][CH2:15][CH2:16][CH3:17])=[N:8][C:7]2=[O:18])(=[O:3])[CH3:2].[BH4-].[Na+]>C(O)C.O>[CH2:14]([C:9]1[NH:10][C:11]2[C:6]([C:7](=[O:18])[N:8]=1)=[CH:5][C:4]([CH:1]([OH:3])[CH3:2])=[CH:13][CH:12]=2)[CH2:15][CH2:16][CH3:17]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 178441846HCID 178441846、化合物

生成物 1

HCID 178441847HCID 178441847、化合物収率 100.2%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a suspension of 0.102 g of 6-acetyl-2-butyl-4(1H)quinazolinone in 10.0 ml of ethanol is added 0.015 g of sodium borohydride. The reaction mixture is stirred for 1.5 hours at room temperature and then diluted with 50 ml of water. The aqueous layer is extracted with 5:1 chloroform-methanol and the combined organics dried over magnesium sulfate, filtered and concentrated in vacuo to yield 0.103 g of the desired product. CI MASS SPEC 247(MH+).

後処理

  1. extractionThe aqueous layer is extracted with 5:1 chloroform-methanol
  2. dry with materialthe combined organics dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-7bcf89b698d54d8ca6e7b49f178a1d77
出典データセット
uspto-grants-1994_03
特許番号
US05290780

反応ノート

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