HCID 178435591、化合物 → 2-butyl-6-ethyl-1H-quinazolin-4-one

HRID 486026ノート

反応式

HRID 486026 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[CH:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([CH2:16][CH3:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

3

反応物 1

HCID 178435591HCID 178435591、化合物

生成物 1

HCID 1784418402-butyl-6-ethyl-1H-quinazolin-4-one収率 63.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a suspension of 0.278 g of 2-butyl-6-ethynyl-4(1H)quinazolinone in 8 ml of pyridine is added 0.080 g of 5% palladium-on-barium sulfate. The reaction is stirred under a hydrogen atmosphere for 48 hours, filtered, concentrated in vacuo and the residue purified by flash chromatography on silica gel eluting with ethyl acetate-hexanes to give 0.179 g of the desired product. CI MASS SPEC 231(MH+).

後処理

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo
  3. customthe residue purified by flash chromatography on silica gel eluting with ethyl acetate-hexanes

出典と根拠

ORDレコード
ord-71898292ecd44a5f99e8a222ce6aab91
出典データセット
uspto-grants-1994_03
特許番号
US05290780

反応ノート

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